Anovelty:pubmed:30695320
open ↗Novelty signal · [Familial Hypercholesterolemia and Its Related Molecules].
Whitespace score 1.00 — pubmed:30695320 previously seen in 0 mission(s).
Anovelty:pubmed:17347037
open ↗Novelty signal · Comparison of B-type natriuretic peptide assays for identifying heart failure in stable elderly patients with a clinical diagnosis of chronic obstructive pulmonary disease.
Whitespace score 1.00 — pubmed:17347037 previously seen in 0 mission(s).
Anovelty:pubmed:38538559
open ↗Novelty signal · Comparing Plasma Donor-derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study.
Whitespace score 1.00 — pubmed:38538559 previously seen in 0 mission(s).
Anovelty:pubmed:12473254
open ↗Novelty signal · Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands.
Whitespace score 1.00 — pubmed:12473254 previously seen in 0 mission(s).
Anovelty:pubmed:37404792
open ↗Novelty signal · StrainNet: Improved Myocardial Strain Analysis of Cine MRI by Deep Learning from DENSE.
Whitespace score 1.00 — pubmed:37404792 previously seen in 0 mission(s).
Novelty signal · Clinical features of familial hypercholesterolemia.
Whitespace score 1.00 — pubmed:2912433 previously seen in 0 mission(s).
Novelty signal · Formin-like protein 5 (FH5)
Whitespace score 1.00 — uniprot:Q94B77 previously seen in 0 mission(s).
Anovelty:pubmed:38910104
open ↗Novelty signal · Application of implementation science for improving the utilization of an international clinical practice guidance on familial hypercholesterolemia.
Whitespace score 1.00 — pubmed:38910104 previously seen in 0 mission(s).
Anovelty:pubmed:24193792
open ↗Novelty signal · Familial hypercholesterolemia: an under-recognized but significant concern in cardiology practice.
Whitespace score 1.00 — pubmed:24193792 previously seen in 0 mission(s).
Novelty signal · Formin-like protein 3 (FH3)
Whitespace score 1.00 — uniprot:O23373 previously seen in 0 mission(s).
Anovelty:pubmed:28434482
open ↗Novelty signal · How to implement clinical guidelines to optimise familial hypercholesterolaemia diagnosis and treatment.
Whitespace score 1.00 — pubmed:28434482 previously seen in 0 mission(s).
Novelty signal · Formin-like protein 8 (FH8)
Whitespace score 1.00 — uniprot:O04532 previously seen in 0 mission(s).
Anovelty:pubmed:26280509
open ↗Novelty signal · α-Klotho Expression in Human Tissues.
Whitespace score 1.00 — pubmed:26280509 previously seen in 0 mission(s).
Anovelty:pubmed:29899171
open ↗Novelty signal · Novel Approaches for the Treatment of Familial Hypercholesterolemia: Current Status and Future Challenges.
Whitespace score 1.00 — pubmed:29899171 previously seen in 0 mission(s).
ADMET scorecard · Formin-like protein 5 (FH5)
Hydrophobicity index: 0.47
Net charge (estimated): -3
Protease risk: Baseline
Half-life class (estimated): Short (<1h)
Developability: Balanced
Novelty signal · Fumarate hydratase, mitochondrial (FH)
Whitespace score 1.00 — uniprot:P07954 previously seen in 0 mission(s).
ADMET scorecard · Formin-like protein 3 (FH3)
Hydrophobicity index: 0.55
Net charge (estimated): 0
Protease risk: Baseline
Half-life class (estimated): Moderate (1–6h)
Developability: Balanced
ADMET scorecard · Formin-like protein 8 (FH8)
Hydrophobicity index: 0.55
Net charge (estimated): -1
Protease risk: Baseline
Half-life class (estimated): Moderate (1–6h)
Developability: Balanced
Anovelty:pubmed:31858669
open ↗Novelty signal · Familial hypercholesterolemia and elevated lipoprotein(a): double heritable risk and new therapeutic opportunities.
Whitespace score 1.00 — pubmed:31858669 previously seen in 0 mission(s).
ADMET scorecard · Fumarate hydratase, mitochondrial (FH)
Hydrophobicity index: 0.55
Net charge (estimated): 5
Protease risk: Baseline
Half-life class (estimated): Improvable with lipidation
Developability: Balanced
Patent landscape · Fh
Estimated patent density: Whitespace
FTO risk: Low
Known ligands (ChEMBL): 0
Recent literature signal: 12 cited PubMed item(s)
[Familial Hypercholesterolemia and Its Related Molecules].
Familial hypercholesterolemia (FH) is a common genetic cause of premature coronary heart disease due to lifelong elevated plasma low-density lipoprotein (LDL) cholesterol levels. However, single gene disorders like FH ha…
Comparison of B-type natriuretic peptide assays for identifying heart failure in stable elderly patients with a clinical diagnosis of chronic obstructive pulmonary disease.
To compare the ability of different B-type natriuretic peptide (BNP) assays to identify heart failure in stable elderly patients with a diagnosis of chronic obstructive pulmonary disease (COPD).
200 patients aged >or=65…
Comparing Plasma Donor-derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study.
Plasma donor-derived cell-free DNA (dd-cfDNA) is used to screen for rejection in heart transplants. We launched the Trifecta-Heart study ( ClinicalTrials.gov No. NCT04707872), an investigator-initiated, prospective trial…
Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands.
To estimate the cost-effectiveness of the current screening programme on Familial Hypercholesterolaemia (FH) in relatives of diagnosed FH-patients in The Netherlands.
Data from 2229 screened FH-relatives, including age,…
StrainNet: Improved Myocardial Strain Analysis of Cine MRI by Deep Learning from DENSE.
To develop a three-dimensional (two dimensions + time) convolutional neural network trained with displacement encoding with stimulated echoes (DENSE) data for displacement and strain analysis of cine MRI.
In this retros…
Clinical features of familial hypercholesterolemia.
The clinical consequences of familial hypercholesterolemia (FH) result from its metabolic peculiarities that persist from very early childhood, leading to the accumulation of cholesterol in the form of xanthomas in skin …
Formin-like protein 5 (FH5)
Organism: Arabidopsis thaliana
Length: 900 aa
Function: Might be involved in the organization and polarity of the actin cytoskeleton. Interacts with the barbed end of actin filaments and nucleates actin-filament polymeri…
Application of implementation science for improving the utilization of an international clinical practice guidance on familial hypercholesterolemia.
The International Atherosclerosis Society (IAS) published an evidence-informed guidance for familial hypercholesterolemia (FH) that provides both clinical and implementation recommendations. We reference examples of stra…
Familial hypercholesterolemia: an under-recognized but significant concern in cardiology practice.
Familial hypercholesterolemia (FH) is a common disorder in which genetic mutations in at least 1 of several genes lead to significantly increased levels of lipoproteins, in particular, low-density lipoprotein cholesterol…